Valproic acid or sodium valproate is a antiepilético and mood stabilizer drug. Operates in several channels of the nervous system and is indicated for the treatment and prophylaxis of epilepsy, migraines and bipolar disorder. Ie it is an existing drug, approved by health authorities and therefore "safe". The insurance I stress that already passed security checks when security was tested for these diseases or pathologies (and other controls that any drug will continue to happen for life) for dispensing in humans by prescription, and therefore no risk any side effects except that every drug has or can have. The relationship between dose and concentration of valproic acid in the blood is nonlinear character. Ie, does not increase the proportion of valproic acid in blood with a higher dose due to saturation of the binding sites on plasma proteins.
Potential side effects and controls.
Mild side effects.
Like any drug valproic acid may have side effects. Milder and common are: drowsiness, dizziness, headaches, diarrhea, constipation, change in appetite, weight change, back pain, agitation, mood swings, thinking abnormal, tremor and blurred vision.
Like any drug valproic acid may have side effects. Milder and common are: drowsiness, dizziness, headaches, diarrhea, constipation, change in appetite, weight change, back pain, agitation, mood swings, thinking abnormal, tremor and blurred vision.
More serious side effects . The most serious side effects may be cases of unusual bruising or bleeding, fever, blisters, hives, difficulty breathing or swallowing, confusion. decreased body temperature and weakness in the joints. Among the highlight side effects and according to my doctors give little hair loss are motivated by accelerated hair growth, leading to a renewal of the fastest hair and usually alarm patients when they see that their hair falls more than usual.
A substantial risk and are only given in rare cases of severe hepatic failure, some with fatal result, especially among children under 3 years. From 3 years old risks are significantly reduced and decline with age. Given a case has been stopping treatment to eliminate valproic acid in the urine within hours. Treatment with valproic acid requires analytical every three months to check liver function and check that everything is in order. In most cases with liver failure appeared in the first 6 months of treatment, with a maximum frequency between the second and twelfth week.
Recent studies found that administration of valproic acid during pregnancy increases the risk of birth defects such as spina bifida (12.7 times), atrial septal defect (2.5), cleft lip (5.2), hypospadias (4.8), polydactyly (2.2) and craniosynostosis (6.8) among others.
It is not recommended use in people with depression because it may cause suicidal thoughts.
Valproic Acid extended release version.
In extended-release drugs (Extended Release, ER) side effects are greatly reduced progressively releasing the dose in the body during the hours to its intake. Thus the side effects or potential for their development are reduced. The formulation of extended release (ER or ER) is coated by a hydrophilic matrix. Drug release is controlled by erosion of the water soluble polymer included in the matrix. With valproic acid in sustained release version absorption begins immediately after administration slowly and steadily over 20 hours. The drug achieves peak plasma level between 4 and 17 hours after administration. The duration of absorption is approximately 21 hours. In patients not on other medication is recommended phasing the drug increasing the dose until reaching the target dose in a week.
Valproic acid and mcardle disease.
Regarding McArdle disease drug isoform regulates brain phosphorylase generating chromatin restructuring allowing the expression of genes that are normally inhibited allowing the expression of the brain and / or liver and muscle compensating for the lack of muscle form of the enzyme.
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